stem cell glue heals arthritis

Stem cell glue mixture may heal arthritisMirand Hitti writing for WebMD reported on a study where scientists used stem cells torepair arthritis damagemice. They tweaked the stem cells' genes to pumpup production of a bonebuilding protein called BMP4. When mice with knee injuries got thosestem cells, their knees healed better than other mice with the same injuries.The finding comes from s including Ryosuke Kuroda, MD, PhD, of Chilen's ofPittsburgh and the University of Pittsburgh. Kuroda's team took stem cells from mouse muscles,placed the stem cellschemical quot;glue,quot;

and used the mixture on mice with knee injuries.Some mice got stem cells that had been genetically altered to make more BMP4. Others got stemcells with normal genes. A third group just got the chemical quot;gluequot; with no stem cells.The mice that got the genetically altered stem cells healed best by the study's end.They made glossy, white tissue that repaired the joint damage quite well.Healing attempts didn't go as wellthe other mice. Their joint repairs were rougherand didn't last as long. Basically, the glue worked like spackle, puttingthe stem cellsthe right spots and fillinglittle gaps. The glue might work betterthan solid grafts of tissue, write Kuroda

and colleagues.Very interesting and promising.

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